Doctors now use cancer-killing viruses to treat some patients with lethal, fast-growing brain tumors. Clinical trials show that these therapeutic viruses are safe but less effective than expected. A new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute shows that the reason for this is in part due to the patient’s own immune system, which quickly works to eliminate the anticancer virus. The findings, published in the journal Nature Medicine, show that the body responds to the anticancer virus as it does to an infection. Read more here.
Study mentioned: Alvarez-Breckenridge CA, et al. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med. 2012 Nov 25. [Epub ahead of print] PMID: 23178246
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