A pathway called the "Unfolded Protein Response," or UPR, a cell's way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma. Research, led by Lori Hart, Ph.D., Constantinos Koumenis, Ph.D., and Davide Ruggero, Ph.D., shows for the first time that the UPR is active in patients with human lymphomas and mice genetically bred to develop lymphomas. Read more here.
Study mentioned: Hart LS, et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Nov 12. [Epub ahead of print] PMID: 23143306
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