Unraveling the mechanism that ovarian cancer cells use to change normal cells around them into cells that promote tumor growth has identified several new targets for treatment of this deadly disease. In Cancer Discovery, a team of researchers from the University of Chicago Medicine and Northwestern University Feinberg School of Medicine show that ovarian cancer cells induce nearby cells to alter their production of three microRNAs—small strands of genetic material that are important regulators of gene expression. Read more here.
Study mentioned: Mitra AK, et al. MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer. Cancer Discov. 2012 Nov 21. [Epub ahead of print] PMID: 23171795
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