Researchers at The University of Texas MD Anderson Cancer Center
have tracked down a cancer-promoting protein's pathway into the cell
nucleus and discovered how, once there, it fires up a glucose metabolism
pathway on which brain tumors thrive. They also found a vital
spot along the protein's journey that can be attacked with a type of
drug not yet deployed against glioblastoma multiforme, the most common
and lethal form of brain cancer. Published online by Nature Cell Biology, the paper further illuminates the importance of pyruvate kinase M2 (PKM2) in cancer development and progression. Read more here.
Study mentioned: Yang W, et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 2012 Nov 25. [Epub ahead of print] PMID: 23178880
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