UC Irvine biologists, chemists and computer scientists have identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs. The finding heralds a new treatment approach, as mutant forms of this protein are implicated in nearly 40 percent of diagnosed cases of cancer, which kills more than half a million Americans each year. In a study published online in Nature Communications, the UC Irvine researchers describe how they employed a computational method to capture the various shapes of the p53 protein. Read more here.
Study mentioned: Wassman CD, et al. Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53. Nat Commun. 2013 Jan 29;4:1407. PMID: 23360998
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