Despite its tragic legacy of causing birth defects 50 years ago, thalidomide — and newer drugs derived from it — has been reborn as an effective treatment for multiple myeloma and other cancers. How they act to slow cancer's spread, however, has long defied explanation. In a new report, scientists at Dana-Farber Cancer Institute say they have discovered that the drugs kill multiple myeloma cells by a mechanism that's different from the way that they cause birth defects. Read more here.
Study mentioned: Lu G, et al. The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins. Science. Published Online November 29 2013.
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