Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease. Read more here.
Study mentioned: Puissant A, et al. (2014) SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia. Cancer Cell. 25(2): 226-242.
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