Weakness exposed in most common cancer gene

NYU Langone Medical Center researchers have found a biological weakness in the workings of the most commonly mutated gene involved in human cancers, known as mutant K-Ras, which they say can be exploited by drug chemotherapies to thwart tumor growth. Mutant K-Ras has long been suspected of being the driving force behind more than a third of all cancers, including colon, lung, and a majority of pancreatic cancers. Read more here.

Study mentioned: Grabocka E, et al. (2014) Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response. Cancer Cell. 25(2): 243-256.