A program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor, scientists at The University of Texas MD Anderson Cancer Center report this week in PNAS. Stuck in what amounts to cellular adolescence, these precursor cells accumulate, contributing to the variability among glioblastoma multiforme cells that make it so difficult to treat, said first author Jian Hu, Ph.D., instructor of Genomic Medicine. Read more here.
Study mentioned: Hu J, et al. Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A. 2013 Aug 5. [Epub ahead of print] PMID: 23918370
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