All cancers are caused by somatic mutations. However, understanding of the biological processes generating these mutations is limited. A group of international researchers led by scientists from the Cancer Genome Project, Wellcome Trust Sanger Institute, one of the world's leading genome centres, analysed 4,938,362 mutations from 7,042 cancers and extracted more than 20 distinct mutational signatures. They published their findings in Nature. Read more here.
Study mentioned: Alexandrov LB, et al. Signatures of mutational processes in human cancer. Nature. 2013 Aug 14. [Epub ahead of print] PMID: 23945592
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