Prostate cancer aggressiveness may be established when the tumor is formed and not alter with time, according to a study published in Cancer Research. Researchers found that after the introduction of widespread prostate-specific antigen screening, the proportion of patients diagnosed with advanced-stage cancers dropped by more than six-fold in 22 years, but the proportion diagnosed with high Gleason grade cancers did not change substantially. This suggests that low-grade prostate cancers do not progress to higher grade over time. Read more here.
Study mentioned: Penney KL, et al. Gleason Grade Progression Is Uncommon. Cancer Res. 2013; 73: 5163.
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