Hormonal therapies can help control advanced prostate cancer for a time. However, for most men, at some point their prostate cancer eventually stops responding to further hormonal treatment. In a study published in Cancer Cell, a team led by researchers at Sanford-Burnham Medical Research Institute found a mechanism at play in androgen-insensitive cells that enables them to survive treatment. Read more here.
Study mentioned: Qi J, et al. The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity. Cancer Cell. 2013; 23(3):322-346.
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