A multi-institutional team led by Massachusetts General Hospital researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children. In their report, they show that blocking this pathway – which involves interactions between tumor cells and the surrounding tissues – leads to regression of all four molecular subtypes of medulloblastoma in several mouse models. Read more here.
Study mentioned: Snuderl M, et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28;152(5):1065-76. PMID: 23452854
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