Researchers at the University of North Carolina at Chapel Hill have discovered that a protein found in the cells surrounding pancreatic cancers play a role in the spread of the disease to other parts of the body. In a finding to be published in Oncogene, researchers in the lab of Carol Otey, PhD, found that the protein palladin enhances the ability of cancer-associated fibroblasts to assemble organelles known as invadopodia to break down the barriers between cells and create pathways for tumors to spread throughout the body. Read more here.
Study mentioned: Goicoechea SM, et al. Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene. 2013 Mar 25. [Epub ahead of print] PMID: 23524582
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