NCI scientists have developed a new paradigm to assess hereditary risk prediction in common diseases, such as prostate cancer. This genetic risk prediction concept is based on polygenic analysis—the study of a group of common DNA sequences, known as single nucleotide polymorphisms (SNPs), each of which contributes a very small amount to overall disease risk, but has a strong effect when grouped together. Read more here.
Study mentioned: Chatterjee N, et al. Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet. 2013 Mar 3. [Epub ahead of print] PMID: 23455638
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