Investigators in The Cancer Genome Atlas Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). Their findings demonstrate that normal metabolism is altered in ccRCC tumor cells, and involves a shift from using one metabolic pathway to another. This change – termed a metabolic shift – correlates with tumor stage and severity in some cases. Read more here.
Study mentioned: The Cancer Genome Atlas Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. Online June 23, 2013.
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