A new study has found that despite an enormous degree of intercellular heterogeneity in both DCIS and IDC, the evolution from non-invasive to invasive disease is determined by recurrent patterns of genomic imbalances in most cases. For patients with cancer, the transition from locally controlled disease to a disseminated stage and metastases is probably the most critical threshold, because that transition makes surgical intervention considerably less likely to succeed, according to study lead investigator Thomas Ried. The researchers looked at gene copy number changes during the transition from DCIS to IDC and, if so, what patterns of genetic imbalances drive this process. Read more here.
Study mentioned: Heselmeyer-Haddad K, et al. Single-Cell Genetic Analysis of Ductal Carcinoma in Situ and Invasive Breast Cancer Reveals Enormous Tumor Heterogeneity yet Conserved Genomic Imbalances and Gain of MYC during Progression. Am J Pathol. 2012 Oct 8. [Epub ahead of print] PMID: 23062488
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