New safety information: Interaction of proton pump inhibitors with methotrexate

Health Canada is informing Canadians and Canadian health care practitioners that the labelling for methotrexate and Proton Pump Inhibitors is being updated to include information on a potential interaction between these products. The new information will be in the "Warnings and Precautions" section of the methotrexate and the PPIs labelling. Methotrexate is used in the treatment of cancer and autoimmune diseases and proton pump inhibitors are acid reducers used in the treatment of heartburn or acid indigestion. The use of these two products at the same time by patients may increase the amount of methotrexate in the blood leading to side effects. Read more here.