Treatment with bevacizumab beyond progression: A new standard in mCRC?

In proffered papers session at ESMO 2012 in Vienna, Dr Gianluca Masi from the University Hospital of Pisa, Italy, presented data from a randomized Phase 3 trial, conducted by the Gruppo Oncologico Nord Ovest (GONO), which evaluated the continuation of bevacizumab beyond progression in patients with mCRC who had received bevacizumab as part of their 1st-line therapy. In this trial, 184 patients who had progressed following 1st-line chemotherapy (FOLFOX, FOLFIRI or FOLFOXIRI) + bevacizumab were randomized to receive 2nd- line treatment with chemotherapy alone (either FOLFOX or mFOLFIRI) or in combination with bevacizumab 5 mg/kg every 2 weeks. Read more here.