Researchers at the Duke-NUS Graduate Medical School in Singapore have identified numerous new subtypes of gastric cancer that are triggered by environmental factors. Reported in the journal Science Translational Medicine, the findings are based on the science of epigenetics. In the study, Dr. Patrick Tan and colleagues used 240 primary tumors and cell lines to conduct the first full survey of the DNA methylation landscape in gastric cancer, known as the methylome. Their goal was to identify new molecular subgroups of gastric cancer not caused by primary genetic mutations, particularly those that might be targeted with therapies. Read more here.
Study mentioned: Zouridis H, et al. Methylation subtypes and large-scale epigenetic alterations in gastric cancer. Sci Transl Med. 2012 Oct 17;4(156):156ra140. PMID: 23076357
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