A team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has solved the mystery of how one of the most powerful of the body’s natural tumor-suppressing proteins, called Chd5, exerts its beneficial effects. The findings, published online in the journal Cell Reports, are important because Chd5 engages processes fundamental to cancer prevention. Conversely, when Chd5 is mutated or missing, an important door is opened to cancer initiation. Read more here.
Study mentioned: Paul S, et al. Chd5 Requires PHD-mediated Histone 3 binding for Tumor Suppression. Online January 10, 2013. Cell Reports.
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