When researchers sequence the RNA of cancer cells, they can compare it to normal cells and see where there is more RNA. That can help lead them to the gene or protein that might be triggering the cancer. But other than spotting a few known instigators, what does it mean? Is there more RNA because it’s synthesizing too quickly or because it’s not degrading fast enough? What part of the biological equilibrium is off? After more than a decade of work, researchers at the University of Michigan Comprehensive Cancer Center have developed a technique to help answer those questions. Read more here.
Study mentioned: Paulsen MT, et al. Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response. PNAS 2013. Published ahead of print January 23, 2013.
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