The tumor suppressor gene p53 is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent – aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing. A team of researchers from the Perelman School of Medicine, University of Pennsylvania, has identified a class of p53 target genes and regulatory molecules that represent promising therapeutic candidates. Read more here.
Study mentioned: Jiang P, et al. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. Published online 13 January 2013)
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