Research by scientists at the NCI has identified a new class of DNA sites in cells that break early in the replication process. They found that these break sites correlate with damage often seen in B cell cancers, such as diffuse large B cell lymphoma. This study is the first to describe an underlying mechanism of genome instability in B cell cancers that could not previously be explained. Results of this finding appear in Cell. Read more here.
Study mentioned: Barlow JH, et al. Identification of Early Replicating Fragile Sites that Contribute to Genome Instability. Cell, 24 January 2013.
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