Prior to this study, published in the Journal of Clinical Investigation, the ribonucleic acid (RNA) molecule called miR-181a had never before been tied to breast cancer metastasis—but when scientists found elevated levels of the molecule in late-stage breast cancer tissues, they tested an inhibitor in mouse models. The approach not only prevented metastasis, but also extended the animals’ lives. Read more here.
Study mentioned: Taylor MA, et al. TGF-β upregulates miR-181a expression to promote breast cancer metastasis. J Clin Invest. 2013 Jan 2;123(1):150-63. PMID: 23241956
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